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  • Overview
  • Benefits
  • Direction
  • Safety
Overview
Feature Comfortis Plus Nexgard Spectra Simparica Trio Credelio Plus
Dosing Frequency Monthly Monthly Monthly Monthly
Minimum Age 8 weeks 8 weeks 8 weeks 8 weeks
Minimum Weight 3.3 lbs (1.5 kg) 4 lbs (1.8 kg) 2.8 lbs (1.3 kg) 4.4 lbs (2.0 kg)
Fleas
Flea Allergy Dermatitis
Black-legged tick
Brown Dog Ticks
American dog tick
Lone star tick
Gulf Coast tick
Longhorned tick
Mites
Heartworm
Roundworms
Hookworms
Whipworm

Comfortis Plus (Trifexis)

Comfortis Plus is an easy-to-dose meat-flavored monthly treatment for dogs. It protects your dogs against fleas, heartworms, and intestinal worms like hookworms, roundworms, whipworms. It starts killing fleas in just 30 minutes of administration, controls flea infestation for a month and also aids in the treatment of flea allergy dermatitis. Comfortis Plus is suitable for use for puppies over 8 weeks of age.

How Comfortis Plus for Dogs Works?

Comfortis Plus contains two key ingredients: spinosad and milbemycin oxime. The active ingredient, spinosad, is an insecticide that attacks the neurons and causes paralysis of the parasite. The second main ingredient, milbemycin oxime, treats other intestinal worms and immature forms of heartworms.

Benefits of The Product
Direction
Safety

Customer Reviews

Reviews
Rating Summary
47 Review(s)
5 star
68.42%
4 star
5.26%
3 star
26.32%
2 star
0%
1 star
0%
Overall Rating

4.0 Star

Average Customer Ratings
Quality of Product
4
Value of Product
4
Pet Satisfaction
4.2
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Effective!
submitted by Max on Mar 07, 2025

I am very satisfied after using this for my pet.

Was this review helpful?
Quality of Product
2.0
Value of Product
2.0
Pet Satisfaction
2.0
Best For Fleas
submitted by Elizabeth on Feb 05, 2025

Very effective flea killer

Was this review helpful?
Quality of Product
2.0
Value of Product
2.0
Pet Satisfaction
2.0
Reliable
submitted by Demetrius on Jan 07, 2025

A monthly dose of effective flea prevention.

Was this review helpful?
Quality of Product
4.0
Value of Product
4.0
Pet Satisfaction
4.0
Great results
submitted by Scout on Dec 06, 2024

Great heartworm preventive for my little one

Was this review helpful?
Quality of Product
4.0
Value of Product
4.0
Pet Satisfaction
4.0
Monthly protection
submitted by Aryan on Nov 02, 2024

Effective protection against fleas on a monthly basis.

Was this review helpful?
Quality of Product
4.0
Value of Product
4.0
Pet Satisfaction
4.0